Mediation and Moderation

Map of Content #MOC Created: 01-07-2022 10:07

  1. Cognitive Reserve can only be identified through some factor moderating the effect of age or pathology on cognition.
  2. The effects of age on cognition are mediated through Age related diseases.
  3. Mediation models range from the simple Three Variable Mediation Model to more sophisticated parallel and serial mediation models.
  4. Parallel mediation
  5. Serial Mediation
  6. Simple Moderation
  7. Flexible modeling of Mediation
  8. Mediation and Moderation for Brain Imaging
  9. Library of Mediation-Moderation Models
  10. References to MatLab Code
  11. New item

Subproject list

  • Generic setup file
    • This includes the direct, interaction, and path matrices
    • There will eventually be a library of these files
  • Analysis setup procedure

    • Select Model setup file (which only defines the model and NOT the data)

      • Check the file for the number of variables that are used

    • Select data to be used for the model

      • This selection procedure will be based on how many variables are needed for the model
      • Data can be imaging data
      • Selected data can be CSV file
        • If CSV data is used, then check to see if there is a header row
        • Check to see how many columns are in the file.
          • If there are more than one variable in the file, then ask the user which variable to use.

    • Parameters to ask of the user 1 Number of bootstraps (default of 1000) * Type of confidence intervals to calculate * Selection from a menu/list * Percentile, Bias-Corrected

      2 Whether to apply TFCE (default of No) * Yes/No 3 What correction for multiple comparisons to use * Selection from a menu/list * None, Family-wise, False-discovery * Where is this done in MatLab?

      • Output from this step will be an analysis setup file specifically for processing the data
  • Prepare Model for Analysis
  • Prepare Model for Analysis Model 6
  • Read setup file
  • Create equations using the data/variables as defined in the setup file
  • Process data/equations
  • Create path values as defined in the setup file, based on results
  • Bootstrapping
  • Calculate confidence intervals on bootstrap results
  • Create a results summary page
  • Create a library of setup files of the most common designs.

References

  1. https://arxiv.org/abs/2106.02482

Notes

CSI4900 Notes

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